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Ibogaine for sale is a naturally occurring psychoactive substance found in plants in the family Apocynaceae such as Tabernanthe iboga, Voacanga Africana, and Tabernaemontana Undulata. It is a psychedelic with dissociative properties. It is also called Bois Sacré, Eboka.
Effects of Ibogaine
Ibogaine and noribogaine interact with multiple neurotransmitter systems. They show a micromolar affinity for N-methyl-D-aspartate (NMDA), κ- and μ-opioid receptors, and sigma-2 receptor sites. Furthermore, ibogaine has been shown to interact with the acetylcholine, serotonin, and dopamine systems; it alters the expression of several proteins including substance P, brain-derived neurotrophic factor (BDNF), c-fos, and EGR-
How does ibogaine work in the brain?
How Does Ibogaine Work in The Brain Ibogaine is an indole alkaloid, which means that it’s a basic chemical, as opposed to acidic. It also contains carbon rings in its chemical structure, which can give it unique properties. For example, its ring structure allows it to mimic serotonin, a naturally occurring chemical in the brain.
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Neurotoxicity: Neurodegeneration was shown in rats, probably mediated by stimulation of the inferior olive, which has excitotoxic effects on Purkinje cells in the cerebellum. Neurotoxic effects of Eboka may not be directly relevant to its anti-addictive properties, as no signs of neurotoxicity were found following doses lower than 25 mg/kg intra-peritoneal in rats. Noribogaine might be less neurotoxic than ibogaine.
Cardiotoxicity: Ether-a-go-go-related gene (hERG) potassium channels in the heart might play a crucial role in ibogaine’s cardiotoxicity, as hERG channels are vital in the repolarization phase of cardiac action potentials and blockade by Eboka delays this repolarization, resulting in QT (time interval between the start of the Q wave and the end of the T wave in the electrical cycle of the heart) interval prolongation and, subsequently, in arrhythmias and sudden cardiac arrest.
Twenty-seven fatalities have been reported following the ingestion of ibogaine, and pre-existing cardiovascular conditions have been implicated in the death of individuals for which post-mortem data were available. However, in this review, 8 case reports are presented which suggests that Eboka caused ventricular tachyarrhythmias and prolongation of the QT interval in individuals without any pre-existing cardiovascular condition or family history. Noribogaine appears at least as harmful to cardiac functioning as Bois Sacré.
Toxicity from drug-drug interaction: Polymorphism in the CYP2D6 enzyme can influence blood concentrations of both Bois Sacré and its primary metabolite, which may have implications when a patient is taking other medication that is subject to significant CYP2D6 metabolism.
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Differences Between Iboga and Ibogaine
With iboga one is immersed in the deep religious and spiritual experience it is used for and most often used amongst the Bwiti tribe. With ibogaine, one is immersed within a compound of the whole and is most often used to heal addiction rather than for religious or spiritual gain.
Pure ibogaine tends to lead to more hyperactivity afterward, whereas iboga results in a more balanced state. Bois Sacré is only one of eleven or more compounds found in the various iboga species.
ibogaine vs ayahuasca:
While both powerful and highly beneficial entheogenic plants, Iboga and Ayahuasca have very different characteristics. Ayahuasca has a feminine spirit; hence it is regarded as Mother Ayahuasca, the Grandmother, or Aya. Iboga, on the other hand, is both masculine and feminine and is often regarded as Grandfather or Godfather.
Ibogaine has been shown to be a very powerful healer for depression, anxiety, and even PTSD. Because Ibogaine targets trauma and promotes healing in the brain, those who suffer from these ailments have found significant relief through Ibogaine treatment.
ibogaine flood dose:
A flood dose of Ibogaine is capable of achieving what Jungian Analysis works to unlock. This is not to say that therapy, with a licensed therapist, both before and after is unnecessary, quite the contrary. It is possible for Ibogaine to unlock the deep recesses of the unconscious, but doing so requires extensive integration, which experienced therapists can help with.
ibogaine treatment costs:
How Much Does Ibogaine Treatment Cost Addiction treatment can be very costly. In the United States, the average 30-day rehab costs $25,000 dollars. When people start researching ibogaine treatment, they automatically assume it will break the bank.
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